A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial CellsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] Activation Adaptive immune response association biochemical Caco2 caused changed chemokine Colon contributed COVID-19 cytokine declining Delta delta variant disease epithelial cell line evade Evolution expected fatality feature highlighting Host Human humans IFN IFN response Infection Innate innate antiviral innate immune response interferon Intervention mechanism multiple mechanism outcome pandemic pathophysiology pathway persistence receptor reduced Replication response resulting RLR pathway robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severe infection severe symptom silent susceptible sustained the disease transcriptomic Treatment vaccination variant variants variants. viral evolution virulence virus with COVID-19 [DOI] 10.1128/spectrum.01604-22 PMC 바로가기
Simultaneous Detection of RIG-1, MDA5, and IFIT-1 Expression Is a Convenient Tool for Evaluation of the Interferon-Mediated ResponseArticle Published on 2022-09-212022-11-15 Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] A549 cell acute phase assumed both virus clinical Course cytosolic cytosolic sensors detection disease onset Disease progression donors elevated evaluated expression Genes H3N2 immune response in vitro in vitro transcribed RNAs influenza A influenza A virus inhibit interferon-stimulated gene interferons ISGs MDA5 Mild-to-moderate mRNA expression mRNA level multiple mechanism multiplex not differ observation onset of symptoms pathogenesis of SARS-CoV-2 patients with influenza post infection qPCR qPCR assay qPCR. remained response RNA RNAs SARS-CoV-2 SARS-CoV-2 patient Signaling Simultaneous SOCS-1 the disease transcribed transfected with type I virus White blood cell White blood cells worsening [DOI] 10.3390/v14102090 PMC 바로가기
The Interaction of Hypericin with SARS-CoV-2 Reveals a Multimodal Antiviral ActivitySARS-CoV-2와 Hypericin의 상호 작용은 다중 모드 항바이러스 활성을 나타냅니다Article Published on 2022-03-302022-09-11 Journal: ACS applied materials & interfaces [Category] SARS, 치료제, [키워드] active against activity antiviral efficacy approach broad-spectrum antivirals component Concentration conditions dark determined by evaluate fluorescence microscopy heterogeneity Hypericin Interaction maximum multiple mechanism Particles photodisinfection photodynamic therapy photosensitization photosensitization. reduce SARS-CoV-2 SARS-CoV-2 infections Treatment Vero E6 VERO E6 cells viral envelope viral particle Viral particles virus virus infectivity viruses [DOI] 10.1021/acsami.1c22439 PMC 바로가기 [Article Type] Article
Computational and In Vitro Experimental Investigations Reveal Anti-Viral Activity of Licorice and Glycyrrhizin against Severe Acute Respiratory Syndrome Coronavirus 2Article Published on 2021-11-242022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] activity Affect Analysis Anti-SARS-CoV-2 Activity antiviral activity antivirals AutoDock binding affinity binding energy clinical trial Compound compounds coronavirus 2 COVID-19 COVID-19 pandemic demonstrated docked docking scores effective glycyrrhiza glycyrrhizic acid glycyrrhizin half-maximal inhibitory concentration highlight IC50 in vivo inhibited investigation licorice Ligand M pro MD simulation multiple mechanism plant Post-infection protease public health Replication respiratory robust SARS-CoV-2 SARS-CoV-2 replication Saudi Arabia screened stability Support the SARS-CoV-2 therapeutic options Treatment Treatment protocol viral infection Viral protein yielding [DOI] 10.3390/ph14121216 PMC 바로가기 [Article Type] Article
Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense숙주 선천적 방어의 다중 메커니즘의 조절에서 SARS-COV-2 비 구조 및 보조 단백질의 새로운 역할에 대한 통찰력Review Published on 2021-10-012022-09-01 Journal: Bosnian Journal of Basic Medical Sciences [Category] 진단, [키워드] accessory protein accessory proteins Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antigen presentation Apoptosis array caused complex coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Defense disease severity disrupting effector molecules Elimination ENhance favor Frame Health Host host immune system IFN-I IFN-I signaling immune evasion immune response immunomodulators Infection Infectious disease Inflammatory mediators insight interferon mediators modulate modulation molecular multiple mechanism nonstructural protein nonstructural proteins Nsps ORFs pathogenic pathway persistence proinflammatory respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Signaling Therapies therapy type I interferon Vaccine Viral viral adaptation virus [DOI] 10.17305/bjbms.2020.5543 PMC 바로가기 [Article Type] Review
Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defenseReview Published on 2021-10-012022-10-27 Journal: Bosnian Journal of Basic Medical Sciences [Category] COVID-19, [키워드] accessory protein accessory proteins Activation acute respiratory syndrome addition Antigen presentation Apoptosis caused complex coronavirus COVID-19 Defense disease severity disrupting effector molecules ENhance favor Frame Health Host host immune system IFN-I IFN-I signaling immune evasion immune response immunomodulators Infection Infectious disease Inflammatory mediators insight interferon modulate modulation molecular multiple mechanism nonstructural protein nonstructural proteins ORFs pathogenic pathway persistence proinflammatory SARS-CoV-2 SARS-COV-2 infection Signaling Therapies therapy type I interferon Vaccine viral adaptation virus [DOI] 10.17305/bjbms.2020.5543 PMC 바로가기 [Article Type] Review
Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defenseReview Published on 2021-10-012022-10-27 Journal: Bosnian Journal of Basic Medical Sciences [Category] Coronavirus, COVID-19, Fulltext, MERS, [키워드] accessory protein accessory proteins Activation acute respiratory syndrome addition Antigen presentation Apoptosis caused complex coronavirus COVID-19 Defense disease severity disrupting effector molecules ENhance favor Frame Health Host host immune system IFN-I IFN-I signaling immune evasion immune response immunomodulators Infection Infectious disease Inflammatory mediators insight interferon modulate modulation molecular multiple mechanism nonstructural protein nonstructural proteins ORFs pathogenic pathway persistence proinflammatory SARS-CoV-2 SARS-COV-2 infection Signaling Therapies therapy type I interferon Vaccine viral adaptation virus [DOI] 10.17305/bjbms.2020.5543 PMC 바로가기 [Article Type] Review
A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19Public Health Published on 2021-07-282022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] accelerate ACE2 ACE2 receptor Affect aggravate airways alveolar cells article ASL blood glucose carbohydrates Cell cell damage cell death cells Combination Complication computational modeling Concentration condition COVID-19 Critical care Cytokine storm database diagnostic disease disease severity dysregulated dysregulation Effect elevated Elevation evade Evidence explain facilitate feasibility Glucose glycemia glycemic control Glycolysis glycosylation hyper-inflammation hyperglycemia Hypothesis immune defense inactivation induce Infection infection process infections Inflammation information innate immune system involved Ketogenic diet knowledge Level lung Lungs machine learning model MOST multi-organ failure multiple mechanism pandemic potential treatments progression proportion provide pulmonary inflammatory response Quantitative reached replicate Replication Research risk role SARS-CoV-2 Severe case severe COVID-19 severity subsequent Symptoms tested the cytokine storm the disease the patient the SARS-CoV-2 Thrombotic events treatment strategy View viral infection Viral load virus weakened [DOI] 10.3389/fpubh.2021.695139 PMC 바로가기 [Article Type] Public Health
Parkinson disease-associated cognitive impairment Reviews Published on 2021-07-012022-10-05 Journal: Nature Reviews Disease Primers [Category] 바이오마커, [키워드] accompanied addition affecting age Biomarker cerebrospinal fluid challenge change changes cholinesterase cognitive Cognitive impairment cortical Dementia disease stage disease-associated executive Features Frequency functional high risk identify impairment include involved Lewy body mechanism memory motor symptom multiple mechanism neurodegenerative disorder occur Older age Other Parkinson disease pathology Patient pharmacological predict Prevalence progression risk risk factor Symptom tested therapy Treatment Variation [DOI] 10.1038/s41572-021-00280-3 [Article Type] Reviews